Rune is an action-adventure video game developed by Human Head Studios which was released in 2000. The game is based on Ragnarok, showing the conflict between the Gods Odin and Loki and the buildup to Ragnarok. Built on the Unreal Engine, the game casts the player as Ragnar, a young Viking warrior whose mettle is tested when Loki and his evil allies plot to destroy the world and bring about Ragnarok.

Upon release, Rune received generally positive reviews. A standalone expansion pack for the game, Rune: Halls of Valhalla, was released in 2001. Both the base game and expansion were ported to Linux by Loki Software. Ryan C. Gordon, a former Loki employee, would also later port Human Head's 2006 title Prey. A port to the PlayStation 2 was also released under the title Rune: Viking Warlord in 2001. The game was re-released digitally under the name Rune Classic in 2012, with the expansion included. A sequel, Rune II, was released in 2019.

A pen-and-paper adaptation of Rune was published by Atlas Games.